Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils

Khurshid A Bhat; Bhahwal A Shah; Kuldeep K Gupta; Anjali Pandey; Sarang Bani; Subhash C Taneja

doi:10.1016/j.bmcl.2009.02.050

Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1939-43. doi: 10.1016/j.bmcl.2009.02.050. Epub 2009 Feb 20.

Authors

Khurshid A Bhat¹, Bhahwal A Shah, Kuldeep K Gupta, Anjali Pandey, Sarang Bani, Subhash C Taneja

Affiliation

¹ Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180001, India.

PMID: 19268586
DOI: 10.1016/j.bmcl.2009.02.050

Abstract

Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.

MeSH terms

Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Gene Expression Regulation
Humans
Inositol / analogs & derivatives*
Inositol / chemical synthesis
Inositol / chemistry
Inositol / pharmacology
Lipopolysaccharides / pharmacology
Neutrophils / drug effects*
Neutrophils / immunology
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / metabolism

Substances

Anti-Inflammatory Agents
Lipopolysaccharides
Tumor Necrosis Factor-alpha
pinitol
Inositol