[Genetics of sarcoidosis: a key to understanding its pathogenesis]

J Müller-Quernheim; M Schürmann; S Hofmann; K I Gaede; A Fischer; A Prasse; G Zissel; S Schreiber

doi:10.1055/s-0028-1100825

[Genetics of sarcoidosis: a key to understanding its pathogenesis]

Pneumologie. 2009 Mar;63(3):166-75. doi: 10.1055/s-0028-1100825.

[Article in German]

Authors

J Müller-Quernheim¹, M Schürmann, S Hofmann, K I Gaede, A Fischer, A Prasse, G Zissel, S Schreiber

Affiliation

¹ Abteilung für Pneumologie, Medizinische Universitätsklinik, Freiburg. [email protected]

PMID: 19271290
DOI: 10.1055/s-0028-1100825

Abstract

Sarcoidosis is a multifactorial and polygenic disorder. The current knowledge of its genetics will be presented and discussed in the context of other granulomatous disorders of known and unknown aetiology. The differing and common features of these disorders lead to the perspective that in near future it will be possible to establish genotype-phenotype correlations which will predict the course and therapy response in an individual case.

Publication types

Review

MeSH terms

Butyrophilins
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
HLA-DQ Antigens / genetics
HLA-DQ beta-Chains
HLA-DR Antigens / genetics
HLA-DRB1 Chains
Humans
Membrane Glycoproteins / genetics*
Sarcoidosis, Pulmonary / diagnosis*
Sarcoidosis, Pulmonary / epidemiology
Sarcoidosis, Pulmonary / genetics*
Sarcoidosis, Pulmonary / therapy

Substances

BTNL2 protein, human
Butyrophilins
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DQB1 antigen
HLA-DR Antigens
HLA-DRB1 Chains
Membrane Glycoproteins