Abstract
The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents* / pharmacology
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Anti-Bacterial Agents* / therapeutic use
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Disease Models, Animal
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Drug Therapy, Combination
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Humans
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Knee Prosthesis / microbiology*
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Levofloxacin*
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Methicillin* / pharmacology
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Microbial Sensitivity Tests
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Ofloxacin* / pharmacology
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Ofloxacin* / therapeutic use
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Rabbits
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Rifampin* / pharmacology
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Rifampin* / therapeutic use
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Levofloxacin
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Ofloxacin
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Methicillin
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Rifampin