Abstract
Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials* / chemistry
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Antimalarials* / isolation & purification
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Antimalarials* / pharmacology
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Antimalarials* / therapeutic use
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Chloroquine / pharmacology
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Chromobacterium / metabolism*
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Drug Resistance
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Humans
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Indoles* / chemistry
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Indoles* / isolation & purification
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Indoles* / pharmacology
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Indoles* / therapeutic use
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Malaria / drug therapy
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Malaria / parasitology
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / parasitology
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Mice
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Mice, Inbred C57BL
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Parasitemia / drug therapy
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Parasitemia / parasitology
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Parasitic Sensitivity Tests
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Plasmodium chabaudi / drug effects*
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / growth & development
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Treatment Outcome
Substances
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Antimalarials
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Indoles
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Chloroquine
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violacein