Abstract
We report an infant with localized pulmonary histoplasmosis in whom Histoplasma antibody assays, quantitative Histoplasma urine and serum antigen concentrations, and histopathologic findings of a mediastinal mass were nondiagnostic. A provisional diagnosis of histoplasmosis was established by using laboratory methods that increase the sensitivity of the antigen assay using ultrafiltration of urine and ethylenediaminetetraacetic acid/heat denaturation of serum proteins.
MeSH terms
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Anti-Inflammatory Agents / therapeutic use
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Antifungal Agents / therapeutic use
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Antigens, Fungal / isolation & purification*
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Antigens, Fungal / urine
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Histoplasma / isolation & purification*
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Histoplasmosis / diagnosis
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Histoplasmosis / drug therapy
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Histoplasmosis / microbiology*
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Hot Temperature
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Humans
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Infant
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Itraconazole / therapeutic use
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Lung Diseases, Fungal / drug therapy
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Lung Diseases, Fungal / microbiology*
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Male
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Prednisone / therapeutic use
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Protein Denaturation*
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Sensitivity and Specificity
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Ultrafiltration / methods
Substances
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Anti-Inflammatory Agents
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Antifungal Agents
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Antigens, Fungal
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Itraconazole
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Prednisone