Abstract
A selective palladium-catalyzed arylation and heteroarylation of 8-oxo-5,6,7,8-tetrahydroindolizines has been developed. Mechanistic studies assume an electrophilic substitution pathway for this transformation. This method provides an efficient one-step synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydroindolizines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Indolizines / chemical synthesis*
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Structure
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Palladium / chemistry*
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Structure-Activity Relationship
Substances
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2-phenyl-5,6,7,8-tetrahydroindolizine
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Heterocyclic Compounds
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Indolizines
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Palladium