Dendrimers ended by non-symmetrical azadiphosphonate groups: synthesis and immunological properties

Patrice Marchand; Laurent Griffe; Mary Poupot; Cédric-Olivier Turrin; Gérard Bacquet; Jean-Jacques Fournié; Jean-Pierre Majoral; Rémy Poupot; Anne-Marie Caminade

doi:10.1016/j.bmcl.2009.03.003

Dendrimers ended by non-symmetrical azadiphosphonate groups: synthesis and immunological properties

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3963-6. doi: 10.1016/j.bmcl.2009.03.003. Epub 2009 Mar 6.

Authors

Patrice Marchand¹, Laurent Griffe, Mary Poupot, Cédric-Olivier Turrin, Gérard Bacquet, Jean-Jacques Fournié, Jean-Pierre Majoral, Rémy Poupot, Anne-Marie Caminade

Affiliation

¹ CNRS, LCC (Laboratoire de Chimie de Coordination), Toulouse, France.

PMID: 19303293
DOI: 10.1016/j.bmcl.2009.03.003

Abstract

The synthesis and characterization of new series of phosphorus-containing dendrimers ended by non-symmetrical azamonophosphonates, or azadiphosphonates, or azadiphosphonic acid salts are reported. The sodium salts of the non-symmetrical azadiphosphonic dendrimers are soluble in water. Their influence towards human immune blood cells is assayed ex vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aza Compounds / chemistry*
Cells, Cultured
Dendrimers / chemical synthesis*
Dendrimers / chemistry
Dendrimers / pharmacology*
Humans
Monocytes / drug effects*
Monocytes / immunology
Organophosphonates / chemistry*

Substances

Aza Compounds
Dendrimers
Organophosphonates