Invasion of the alveolar-capillary barrier by Aspergillus spp.: therapeutic and diagnostic implications for immunocompromised patients with invasive pulmonary aspergillosis

William W Hope

doi:10.1080/13693780802510232

Invasion of the alveolar-capillary barrier by Aspergillus spp.: therapeutic and diagnostic implications for immunocompromised patients with invasive pulmonary aspergillosis

Med Mycol. 2009:47 Suppl 1:S291-8. doi: 10.1080/13693780802510232. Epub 2009 Mar 21.

Author

William W Hope¹

Affiliation

¹ The University of Manchester, Manchester, UK. [email protected]

PMID: 19306226
DOI: 10.1080/13693780802510232

Abstract

Aspergillus spp. are leading causes of morbidity and mortality in immunocompromised patients. This review provides an overview of host defenses, the mechanisms by which the alveolar-capillary barrier is breeched by Aspergillus, and the implications for diagnosis and treatment of patients with invasive pulmonary aspergillosis.

Publication types

Review

MeSH terms

Aspergillus / growth & development*
Aspergillus / immunology*
Humans
Immunocompromised Host*
Invasive Pulmonary Aspergillosis / drug therapy
Invasive Pulmonary Aspergillosis / immunology
Invasive Pulmonary Aspergillosis / microbiology*
Invasive Pulmonary Aspergillosis / pathology*
Lung / immunology
Lung / microbiology
Lung / pathology