The use of allografts in sports medicine is becoming increasingly popular, and, therefore, this issue of Clinics in Sports Medicine is dedicated to the use of allografts in sports medicine. The majority of indications are related to the use of soft tissue grafts for ligament reconstruction, osteochondral (OC) allografts for articular surface reconstruction, and meniscal allografts for meniscal transplantation. There is an increasing amount of science and literature dealing with healing and outcomes, but many questions still remain. There are a number of issues, controversies, and lack of long-term outcomes to make definitive statements on what is really known about allograft use in sports medicine.