Abnormalities of insulin and lipid metabolism in Milan hypertensive rats

Am J Hypertens. 1991 Sep;4(9):773-5. doi: 10.1093/ajh/4.9.773.

Abstract

Plasma glucose, insulin, triglyceride, and cholesterol concentrations were measured in male rats of the Milan hypertensive strain (MHS) and compared to the Milan normotensive strain (MNS) of the same body weight. Both blood pressure (P less than .001) and left ventricular weight (P less than .005) were higher in rats of the MHS. Although plasma glucose concentrations were similar in both groups, mean (+/- SEM) plasma insulin concentration were significantly higher (P less than .01) in MHS as compared to MNS rats (30 +/- 4 v. 13 +/- 5 microU/mL). In addition mean (+/- SEM) plasma triglyceride concentrations were higher (P less than .01) in MHS rats (112 +/- 9 mg/dL) than in MNS rats (81 +/- 6 mg/dL), as were plasma cholesterol concentrations (114 +/- 3 v 100 +/- 2 mg/dL, P less than .001). These data demonstrate the presence of hyperinsulinemia and hypertriglyceridemia in another genetic model of rat hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Body Weight / drug effects
  • Body Weight / physiology
  • Cholesterol / blood
  • Hyperinsulinism / blood
  • Hypertension / complications
  • Hypertension / genetics
  • Hypertension / metabolism*
  • Insulin / blood
  • Insulin / metabolism*
  • Lipid Metabolism*
  • Lipids / blood
  • Male
  • Models, Genetic
  • Rats
  • Rats, Inbred SHR / metabolism*
  • Rats, Inbred Strains
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Insulin
  • Lipids
  • Triglycerides
  • Cholesterol