Metastatic renal cell cancer: interleukin-2 toxicity induced by contrast agent injection

J Immunother (1991). 1991 Aug;10(4):292-5.

Abstract

We describe a clinical syndrome occurring after contrast medium injection in patients who previously received recombinant interleukin-2 (rIL-2) and recombinant interferon-alpha 2A treatment for metastatic renal cancer. The clinical picture mimics many aspects of rIL-2-related systemic side effects. The patients were managed conservatively but the potential for severe manifestations can occur, requiring more intensive treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Renal Cell / therapy*
  • Contrast Media / adverse effects*
  • Drug Interactions
  • Humans
  • Immunotherapy
  • Interferon Type I / therapeutic use
  • Interleukin-2 / adverse effects*
  • Interleukin-2 / therapeutic use
  • Kidney Neoplasms / therapy*
  • Neoplasm Metastasis
  • Recombinant Proteins / adverse effects
  • Recombinant Proteins / therapeutic use

Substances

  • Contrast Media
  • Interferon Type I
  • Interleukin-2
  • Recombinant Proteins