Correlated connectivity and the distribution of firing rates in the neocortex

J Neurosci. 2009 Mar 25;29(12):3685-94. doi: 10.1523/JNEUROSCI.4500-08.2009.

Abstract

Two recent experimental observations pose a challenge to many cortical models. First, the activity in the auditory cortex is sparse, and firing rates can be described by a lognormal distribution. Second, the distribution of nonzero synaptic strengths between nearby cortical neurons can also be described by a lognormal distribution. Here we use a simple model of cortical activity to reconcile these observations. The model makes the experimentally testable prediction that synaptic efficacies onto a given cortical neuron are statistically correlated, i.e., it predicts that some neurons receive stronger synapses than other neurons. We propose a simple Hebb-like learning rule that gives rise to such correlations and yields both lognormal firing rates and synaptic efficacies. Our results represent a first step toward reconciling sparse activity and sparse connectivity in cortical networks.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Action Potentials*
  • Animals
  • Models, Neurological*
  • Neocortex / physiology*
  • Nerve Net / physiology
  • Neurons / physiology
  • Synapses / physiology