Intricate links between ER stress and apoptosis

Frank Madeo; Guido Kroemer

doi:10.1016/j.molcel.2009.03.002

Intricate links between ER stress and apoptosis

Mol Cell. 2009 Mar 27;33(6):669-70. doi: 10.1016/j.molcel.2009.03.002.

Authors

Frank Madeo¹, Guido Kroemer

Affiliation

¹ Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.

PMID: 19328058
DOI: 10.1016/j.molcel.2009.03.002

Abstract

Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.

Publication types

Comment

MeSH terms

Apoptosis / physiology*
Apoptosis Regulatory Proteins / genetics
Apoptosis Regulatory Proteins / metabolism*
Endoplasmic Reticulum / physiology*
Endoribonucleases / genetics
Endoribonucleases / metabolism*
Humans
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*

Substances

Apoptosis Regulatory Proteins
Membrane Proteins
TMBIM6 protein, human
ERN1 protein, human
Protein Serine-Threonine Kinases
Endoribonucleases