Abstract
Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Animals
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Chemokine CCL5 / administration & dosage
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Chemokine CCL5 / therapeutic use*
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Chemokines / administration & dosage
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Chemokines / genetics
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Chemokines / therapeutic use*
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Female
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Macaca
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RNA, Viral / blood
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RNA, Viral / genetics
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / therapeutic use
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Reverse Transcriptase Polymerase Chain Reaction
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Simian Acquired Immunodeficiency Syndrome / prevention & control*
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Vagina / virology*
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Viral Load
Substances
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Chemokine CCL5
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Chemokines
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RANTES, N(alpha)-(n-nonanoyl)-desSer(1)-(thioproline(2),cyclohexylglycine(3))-
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RNA, Viral
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Recombinant Proteins