This paper describes the activities carried out in order to make an e-learning system for CME be a good tool in terms of usability. The following steps are described:--the needs analysis of the potential users;--the prototype of the e-learning system that has been set up;--the usability evaluation of the prototype by a sample often users before and after the implementation of the identified remedial actions. The obtained results support the hypothesis of an effective usage of the system in the near future. The follow-up of real users' usage, through the tracing facilities of the e-learning platform, will confirm or reject our hypothesis.