beta-tting on p63 as a metastatic suppressor

John G Clohessy; Pier Paolo Pandolfi

doi:10.1016/j.cell.2009.03.028

beta-tting on p63 as a metastatic suppressor

Cell. 2009 Apr 3;137(1):28-30. doi: 10.1016/j.cell.2009.03.028.

Authors

John G Clohessy¹, Pier Paolo Pandolfi

Affiliation

¹ Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

PMID: 19345184
DOI: 10.1016/j.cell.2009.03.028

Abstract

Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor beta.

Publication types

Comment

MeSH terms

Animals
Humans
Neoplasm Metastasis*
Trans-Activators / metabolism*
Transcription Factors
Transforming Growth Factor beta / metabolism
Tumor Suppressor Protein p53 / metabolism
Tumor Suppressor Proteins / metabolism*

Substances

TP63 protein, human
Trans-Activators
Transcription Factors
Transforming Growth Factor beta
Tumor Suppressor Protein p53
Tumor Suppressor Proteins