Abstract
Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC(50) values of 227.5 and 362.1 microg/ml, respectively. The most abundant constituents of the extract were trans-anethole, (+)-limonene and (+)-sabinene. trans-Anethole exhibited the highest activity against AChE and BChE with IC(50) values of 134.7 and 209.6 microg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml).
MeSH terms
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Acetylcholinesterase / metabolism*
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Allylbenzene Derivatives
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Anisoles / isolation & purification
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Anisoles / pharmacology
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Bicyclic Monoterpenes
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Butyrylcholinesterase / metabolism*
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology*
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Cyclohexenes / isolation & purification
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Cyclohexenes / pharmacology
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Fruit
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Limonene
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Monoterpenes / isolation & purification
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Monoterpenes / pharmacology
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Pimpinella / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plants, Medicinal / chemistry
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Terpenes / isolation & purification
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Terpenes / pharmacology
Substances
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Allylbenzene Derivatives
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Anisoles
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Bicyclic Monoterpenes
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Cholinesterase Inhibitors
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Cyclohexenes
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Monoterpenes
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Plant Extracts
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Terpenes
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sabinene
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Limonene
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Acetylcholinesterase
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Butyrylcholinesterase
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anethole