MicroRNA expression profiles in thyroid tumors

Endocr Pathol. 2009 Summer;20(2):85-91. doi: 10.1007/s12022-009-9069-z.

Abstract

MicroRNAs (miRNAs) constitute a recently identified class of small endogenous noncoding RNAs that act as negative regulators of the protein-coding gene expression and may impact cell differentiation, proliferation and survival, i.e., all fundamental cellular processes implicated in carcinogenesis. miRNA expression is deregulated in many types of human cancers, including thyroid cancer. The purpose of this review is to summarize the existing findings of miRNA deregulation in thyroid tumors and its potential role in thyroid cancer biology and molecular diagnostics.

Publication types

  • Review

MeSH terms

  • Carcinoma, Papillary / genetics
  • Carcinoma, Papillary / metabolism
  • Cyclin-Dependent Kinase Inhibitor p27
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • MicroRNAs / metabolism*
  • Mutation
  • Proto-Oncogene Proteins c-kit / genetics
  • Proto-Oncogene Proteins c-kit / metabolism
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / genetics*
  • Thyroid Neoplasms / metabolism

Substances

  • CDKN1B protein, human
  • Intracellular Signaling Peptides and Proteins
  • MIRN221 microRNA, human
  • MIRN222 microRNA, human
  • MicroRNAs
  • Cyclin-Dependent Kinase Inhibitor p27
  • Proto-Oncogene Proteins c-kit