This study analyzed polyhalogenated compounds (PHCs) such as brominated flame retardants (BFRs) in indoor air and dust samples from two modern homes in Japan. Concentrations of polychlorinated biphenyls (PCBs) and 2,4,6-tribromophenol (2,4,6-TBP) in exhaust and indoor air of two houses were detected at 10(2)-10(3)pgm(-3) order, which were well above those in outdoor air. For dust samples, the detected polybrominated diphenyl ether (PBDE) and polybrominated dibenzo-p-dioxins/furan concentrations resembled values found in our past study. Interestingly, compared to PBDE concentrations, two orders of magnitude higher concentration (13000 ng g(-1)) was observed for hexabromocyclododecanes (HBCDs) in a dust sample from one house. Based on the calculation of air/dust partition ratio values (Kad), low Kad values (log Kad <or=0) were obtained for high brominated PBDEs (pentaBDEs - decaBDE), tetrabromobisphenol A (TBBPA), and HBCDs, although indoor air contained higher contents of low chlorinated PCBs, low brominated PBDEs, and 2,4,6-TBP. Attention should be given to exposure to 2,4,6-TBP through inhalation of air as well as dust ingestion. Results of X-ray fluorescence analysis show high bromine concentrations in curtain and roll screen samples possessing a high product loading factor. Furthermore, a preliminary estimation was made of the likely magnitude of inhabitants' exposure to PHCs via inhalation and dust ingestion in the two houses.