Abstract
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents, Local / chemical synthesis*
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Anti-Infective Agents, Local / chemistry
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Anti-Infective Agents, Local / pharmacology
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Chloramines / chemical synthesis
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Chloramines / chemistry*
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Microbial Sensitivity Tests
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Quaternary Ammonium Compounds / chemical synthesis
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Quaternary Ammonium Compounds / chemistry*
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Structure-Activity Relationship
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Sulfhydryl Compounds / chemical synthesis*
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Sulfhydryl Compounds / chemistry
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Sulfhydryl Compounds / pharmacology
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Sulfonic Acids / chemical synthesis
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Sulfonic Acids / chemistry
Substances
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2-dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt
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Anti-Infective Agents, Local
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Chloramines
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Quaternary Ammonium Compounds
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Sulfhydryl Compounds
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Sulfonic Acids