Abstract
A remarkable prevalence of qnrB (54%) and, at a lower level, of qnrS (14%) was discovered in pools of commensal enterobacteria from 310 healthy children living in Peru and Bolivia, using a metagenomic approach. Analysis of randomly selected enterobacterial pools revealed that qnrB was mainly carried by Escherichia coli and qnrS by Klebsiella pneumoniae. Investigation of 11 qnrB-positive isolates and 9 qnrS-positive isolates revealed the presence of plasmid-borne qnrB19 (n = 8), qnrB2 (n = 2), qnrB10 (n = 1), and qnrS1 (n = 9) genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics*
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Base Sequence
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Bolivia
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Child
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Child, Preschool
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Drug Resistance, Bacterial / genetics*
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli Proteins / genetics*
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Humans
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Infant
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Molecular Sequence Data
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Peru
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Plasmids
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Polymerase Chain Reaction
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Quinolones / pharmacology*
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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Qnr protein, E coli
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Qnr protein, Klebsiella pneumoniae
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Quinolones