Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia

Tae-Jin Han; Chang-Hun Lee; Chong-Woo Yoo; Hye-Jin Shin; Hyun-Jin Park; Kwan Ho Cho; Joo-Yong Park; Sung-Won Choi; Joo-Young Kim

doi:10.1016/j.radonc.2009.03.009

Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia

Radiother Oncol. 2009 Jul;92(1):138-41. doi: 10.1016/j.radonc.2009.03.009. Epub 2009 May 4.

Authors

Tae-Jin Han¹, Chang-Hun Lee, Chong-Woo Yoo, Hye-Jin Shin, Hyun-Jin Park, Kwan Ho Cho, Joo-Yong Park, Sung-Won Choi, Joo-Young Kim

Affiliation

¹ Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.

PMID: 19368986
DOI: 10.1016/j.radonc.2009.03.009

Abstract

We report the case of a 32-year-old woman who presented with multiple squamous cell neoplasms synchronously arising in the cervix, vulva, oral cavity and oropharynx. During the period when the patient was treated by radiotherapy, she developed severe radiation mucositis and pancytopenia. Immunofluorescence staining for foci of the monoubiquitinated form of FANCD2 revealed a complete absence of such foci in all cancer tissues that were examined.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Carcinoma, Squamous Cell / complications*
Carcinoma, Squamous Cell / virology
Fanconi Anemia / complications*
Female
Genital Neoplasms, Female / complications*
Genital Neoplasms, Female / virology
Head and Neck Neoplasms / complications*
Head and Neck Neoplasms / virology
Humans
Papillomavirus Infections / complications*
Papillomavirus Infections / virology