Abstract
Drug Hypersensitivity Syndrome, also known as Drug Rash with Eosinophilia and Systemic Symptoms is a severe adverse reaction characterized by clinical manifestations including fever, skin eruption, lymphoadenopathy, associated with eosinophilia, leukocytosis and multiple visceral involvement, with 10% of mortality due to development of multiple organ failure. This reaction usually occurs between two and six-eight weeks after the beginning of the treatment and may not resolve with interruption of the suspected drug. Sulfonamides, anticonvulsant, allopurinol are the most frequently involved molecules, but recently cases have been described also with gabapentin and strontium ranelate. In the present report we describe a case of a patient with rheumatoid arthritis who presented severe drug hypersensitivity syndrome, with liver and kidney involvement due to sulphasalazine.
Publication types
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Case Reports
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Comparative Study
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English Abstract
MeSH terms
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / therapeutic use
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / adverse effects*
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Arthritis, Rheumatoid / drug therapy*
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Diagnosis, Differential
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Drug Eruptions / diagnosis
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Drug Eruptions / drug therapy
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Drug Eruptions / etiology
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Drug Hypersensitivity / diagnosis
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Drug Hypersensitivity / drug therapy
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Drug Hypersensitivity / etiology*
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Glucocorticoids / administration & dosage
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Glucocorticoids / therapeutic use
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Humans
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Male
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Methylprednisolone / administration & dosage
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Methylprednisolone / therapeutic use
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Middle Aged
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Remission Induction
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Sulfasalazine / administration & dosage
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Sulfasalazine / adverse effects*
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Syndrome
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Time Factors
Substances
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Anti-Inflammatory Agents
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Antirheumatic Agents
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Glucocorticoids
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Sulfasalazine
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Methylprednisolone