Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress

Nat Prod Commun. 2009 Feb;4(2):221-6.

Abstract

The protective effect of myricetin against tert-butylhydroperoxide (t-BHP) induced oxidative stress in human erythrocytes was investigated. Incubating erythrocytes with t-BHP (10(-5) M) caused development of oxidative stress, as evidenced by significant (p < 0.05) increase in erythrocyte malondialdedyde (MDA) and protein carbonyl content, and decrease in intracellular reduced glutathione (GSH), membrane sulphydryl (-SH) groups. Incubation of erythrocytes with myricetin, simultaneously with t-BHP, protected the erythrocytes from oxidative stress, an effect which was dose-dependent. The results demonstrate that myricetin attenuates t-BHP induced oxidative damage, suggesting that supplementation of diet with myricetin/myricetin rich food may be beneficial in all pathological conditions where the antioxidant system of the body is overwhelmed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / metabolism*
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism*
  • Flavonoids / chemistry*
  • Humans
  • Molecular Structure
  • Oxidative Stress*
  • tert-Butylhydroperoxide / toxicity

Substances

  • Biomarkers
  • Flavonoids
  • myricetin
  • tert-Butylhydroperoxide