Abstract
The ASSOCIATE study investigators have reported that the I(f) current inhibitor, ivabradine, is safe, improves exercise performance, and delays the development of ischemia in patients with chronic stable angina beingtreated with atenolol. ivabradine should be considered in the medical management of symptom-limited patients with angina, when heart rate is suboptimally controlled.
MeSH terms
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Adrenergic beta-Antagonists / therapeutic use
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Angina Pectoris / drug therapy*
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Angina Pectoris / physiopathology
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Anti-Arrhythmia Agents / therapeutic use*
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Atenolol / therapeutic use
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Benzazepines / therapeutic use*
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Chronic Disease
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Drug Therapy, Combination
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Exercise Tolerance / drug effects
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Heart Rate / drug effects
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Humans
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Ivabradine
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Treatment Outcome
Substances
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Adrenergic beta-Antagonists
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Anti-Arrhythmia Agents
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Benzazepines
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Ivabradine
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Atenolol