Interleukin-1 administration to C3H/HeJ mice after but not prior to infection increases resistance to Salmonella typhimurium

P J Morrissey; K Charrier

doi:10.1128/iai.59.12.4729-4731.1991

Interleukin-1 administration to C3H/HeJ mice after but not prior to infection increases resistance to Salmonella typhimurium

Infect Immun. 1991 Dec;59(12):4729-31. doi: 10.1128/iai.59.12.4729-4731.1991.

Authors

P J Morrissey¹, K Charrier

Affiliation

¹ Immunex Corporation, Seattle, Washington 98101.

Abstract

Interleukin-1 (IL-1) treatment of C3H/HeN and C3H/HeJ mice prior to infection with Salmonella typhimurium increased the survival fraction only in C3H/HeN mice. IL-1 administration after infection resulted in a significant increase in mean survival time in C3H/HeJ but not C3H/HeN mice. Bacterial growth in IL-1-treated C3H/HeJ mice was less than that in control mice.

MeSH terms

Animals
Female
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
Interleukin-1 / pharmacology*
Mice
Mice, Inbred C3H
Salmonella Infections, Animal / immunology*
Salmonella typhimurium*

Substances

Interleukin-1
Granulocyte-Macrophage Colony-Stimulating Factor