Abstract
Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Interleukin-15 (IL-15) produced by and trans-presented on the membrane of the CD11c(+) dendritic cells (DCs) is the key factor that mediates homeostatic competition between CD8 and gammadelta T cells, revealing previously unrecognized IL-15-dependent homeostatic mechanisms between different T-cell subsets in vivo.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adoptive Transfer
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Animals
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CD11c Antigen / analysis
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CD8-Positive T-Lymphocytes / immunology*
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Cell Division
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Dendritic Cells / immunology*
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Genes, RAG-1
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Homeostasis / immunology
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Interleukin-15 / deficiency
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Interleukin-15 / genetics
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Interleukin-15 / immunology
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Interleukin-15 / pharmacology
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Interleukin-15 / physiology*
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Lymphocyte Activation
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Lymphocyte Depletion
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Lymphopenia / immunology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Radiation Chimera
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Receptors, Antigen, T-Cell, alpha-beta / deficiency
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Receptors, Antigen, T-Cell, gamma-delta / immunology*
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Receptors, Interleukin-15 / immunology
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Recombinant Proteins / pharmacology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / transplantation
Substances
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CD11c Antigen
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Interleukin-15
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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Receptors, Interleukin-15
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Recombinant Proteins