Abstract
A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensis has yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1-3 were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Crystallography, X-Ray
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Papua New Guinea
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Parasitic Sensitivity Tests
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Porifera / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / classification
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Trypanosoma brucei brucei / drug effects
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Trypanosomiasis, African / drug therapy
Substances
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Sesquiterpenes
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aignopsanoic acid A
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methyl aignopsanoate A