Abstract
In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Acetyltransferases / metabolism
-
Animals
-
Core Binding Factor Alpha 2 Subunit / chemistry
-
Core Binding Factor Alpha 2 Subunit / genetics*
-
Core Binding Factor Alpha 2 Subunit / metabolism*
-
DNA Methylation
-
Histone Deacetylases / metabolism
-
Humans
-
Methyltransferases / metabolism
-
Protein Processing, Post-Translational*
Substances
-
Core Binding Factor Alpha 2 Subunit
-
Methyltransferases
-
Acetyltransferases
-
Histone Deacetylases