Case 41. A misdiagnosis of erythroleukemia

Leuk Lymphoma. 2009 Jun;50(6):1030-2. doi: 10.1080/10428190902912494.

Abstract

A 57-year-old woman with splenomegaly, moderate anemia and a paraspinal mass was found to have strikingly increased erythropoiesis, which was left shifted and dysplastic with many multinucleated cells. An increased percentage of CD34-positive and CD117-positive cells suggested a diagnosis of pure erythroleukemia. Further investigations were performed.

Publication types

  • Case Reports

MeSH terms

  • Anion Exchange Protein 1, Erythrocyte / analysis
  • Antigens, CD34 / analysis*
  • Blood Protein Electrophoresis
  • Bone Marrow Examination
  • Diagnosis, Differential
  • Diagnostic Errors / prevention & control
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Flow Cytometry
  • Giant Cells / pathology
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Leukemia, Erythroblastic, Acute / diagnosis*
  • Leukemia, Erythroblastic, Acute / metabolism
  • Middle Aged
  • Proto-Oncogene Proteins c-kit / analysis*
  • Splenomegaly / pathology

Substances

  • Anion Exchange Protein 1, Erythrocyte
  • Antigens, CD34
  • Proto-Oncogene Proteins c-kit