Abstract
Guanosine 5'-(tri)diphosphate, 3'-diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription-regulator of genes related to important bacterial metabolic processes. Therefore, more attention should be focused on the molecular mechanisms of (p) ppGpp, as it is the foundation to understanding how bacteria adapt to extreme circumstances through the stringent response.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adaptation, Physiological
-
Bacteria* / genetics
-
Bacteria* / metabolism
-
Bacterial Proteins / genetics
-
Bacterial Proteins / metabolism*
-
DNA-Directed RNA Polymerases / chemistry
-
DNA-Directed RNA Polymerases / genetics
-
DNA-Directed RNA Polymerases / metabolism
-
Gene Expression Regulation, Bacterial*
-
Guanosine Pentaphosphate / chemistry
-
Guanosine Pentaphosphate / metabolism*
-
Isoenzymes / genetics
-
Isoenzymes / metabolism
-
Ligases / genetics
-
Ligases / metabolism
-
Models, Molecular
-
Molecular Structure
-
Plant Proteins / genetics
-
Plant Proteins / metabolism
-
Protein Conformation
-
Pyrophosphatases / genetics
-
Pyrophosphatases / metabolism
Substances
-
Bacterial Proteins
-
Isoenzymes
-
Plant Proteins
-
Guanosine Pentaphosphate
-
DNA-Directed RNA Polymerases
-
guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase
-
Pyrophosphatases
-
Ligases
-
guanosine 3',5'-polyphosphate synthetases