Hereditary leukonychia totalis, acanthosis-nigricans-like lesions and hair dysplasia: a new syndrome?

Eur J Med Genet. 2009 Jul-Aug;52(4):229-33. doi: 10.1016/j.ejmg.2009.04.003. Epub 2009 May 4.

Abstract

Leukonychia is an ungueal discoloration or dyschromia. The hereditary form is rare. In the observations reported in the literature, leukonychia was total or sub-total, and was sometimes associated to other various symptoms. We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family.

MeSH terms

  • Acanthosis Nigricans / complications*
  • Acanthosis Nigricans / pathology
  • Child
  • Fathers
  • Female
  • Genes, Dominant
  • Hair / abnormalities*
  • Hair / ultrastructure
  • Humans
  • Male
  • Nail Diseases / genetics*
  • Nuclear Family
  • Pedigree
  • Syndrome