Abstract
Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Antigens, Neoplasm / analysis
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Antigens, Neoplasm / genetics
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Antigens, Neoplasm / urine
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / urine*
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Exosomes / genetics
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Exosomes / pathology*
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Humans
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Male
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Oncogene Proteins, Fusion / analysis
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / urine
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Prostatic Neoplasms / diagnosis*
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / pathology
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Prostatic Neoplasms / urine*
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RNA, Messenger / analysis
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Urinalysis / methods
Substances
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Antigens, Neoplasm
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Biomarkers, Tumor
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Oncogene Proteins, Fusion
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RNA, Messenger
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TMPRSS2-ERG fusion protein, human
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prostate cancer antigen 3, human