Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation

J Neurooncol. 2009 Oct;95(1):71-80. doi: 10.1007/s11060-009-9893-5. Epub 2009 Apr 30.

Abstract

Papillary glioneuronal tumors are newly recognized seizure producing tumors. We report two such cases with immunohistochemical characterization of glial and neuronal components and briefly review literature. Co-localization of glial and neuronal markers was demonstrable on confocal microscopy with expression of stem cell markers (Nestin and CD133) suggesting possible origin from neuroepithelial stem cell with biphenotypic differentiation.

Publication types

  • Case Reports

MeSH terms

  • AC133 Antigen
  • Adult
  • Antigens, CD / metabolism
  • Brain Neoplasms / pathology*
  • Carcinoma, Papillary / pathology*
  • Glycoproteins / metabolism
  • Humans
  • Male
  • Meningioma
  • Middle Aged
  • Neoplastic Stem Cells / pathology*
  • Nerve Tissue Proteins / metabolism
  • Neuroglia / pathology*
  • Neurons / pathology*
  • Peptides / metabolism

Substances

  • AC133 Antigen
  • Antigens, CD
  • Glycoproteins
  • Nerve Tissue Proteins
  • PROM1 protein, human
  • Peptides