Abstract
H(3)R inverse agonists based on an aminopropoxy-phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.
MeSH terms
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Animals
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CHO Cells
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Caco-2 Cells
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Cell Line
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Cricetinae
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Cricetulus
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Drug Design
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Drug Inverse Agonism
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Histamine H3 Antagonists / chemical synthesis
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Histamine H3 Antagonists / chemistry
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Histamine H3 Antagonists / pharmacology*
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Humans
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Imidazoles / chemistry
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Mice
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Oxazoles / chemical synthesis
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Oxazoles / chemistry
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Oxazoles / pharmacology*
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Prefrontal Cortex / drug effects
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Rats
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Rats, Wistar
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Receptors, Histamine H3 / chemistry*
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Receptors, Histamine H3 / metabolism
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Structure-Activity Relationship
Substances
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Histamine H3 Antagonists
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Imidazoles
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Oxazoles
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Receptors, Histamine H3
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imidazole