Persistence of HIV-1 silent infection in seronegative subjects at high risk

J Med Virol. 1991 Sep;35(1):14-8. doi: 10.1002/jmv.1890350104.

Abstract

Twenty regular sexual partners of HIV-1 infected subjects, without detectable human immunodeficiency virus (HIV-1) antibody and positive for HIV-1 genome by in situ hybridization (ISH), were selected and studied longitudinally for 6-36 months to estimate the duration of silent infection. During the follow-up period, 10 showed atypical Western Blot (WB) patterns. Two seronegative partners seroconverted. Rapid progress to AIDS was observed in 7 seropositive subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blotting, Western
  • Carrier State / immunology*
  • Female
  • Follow-Up Studies
  • HIV Infections / immunology*
  • HIV Seropositivity
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nucleic Acid Hybridization
  • Risk Factors
  • Sexual Partners*