Primary testicular presentation of ALK-1-negative anaplastic large cell lymphoma in a pediatric patient

J Pediatr Hematol Oncol. 2009 May;31(5):330-2. doi: 10.1097/MPH.0b013e3181979c5e.

Abstract

Anaplastic large cell lymphoma is a heterogeneous group of malignant non-Hodgkin lymphomas that occurs in up to 15% of all pediatric non-Hodgkin lymphomas. It is characterized by B-symptoms and involvement of extranodal sites such as skin, bone, and soft tissue. This brief report describes first reported case of pediatric primary testicular anaplastic large cell lymphoma in a 14-year-old boy. The presentation included acute testicular pain, fever, and vomiting. After chemotherapy and unilateral radical orchiectomy, patient continues in complete remission.

MeSH terms

  • Activin Receptors, Type II / metabolism*
  • Adolescent
  • Biomarkers, Tumor / metabolism
  • Biopsy
  • Cell Nucleus / metabolism
  • Cell Nucleus / pathology
  • Golgi Apparatus / metabolism
  • Golgi Apparatus / pathology
  • Humans
  • Ki-1 Antigen / metabolism
  • Lymphoma, Large B-Cell, Diffuse / metabolism*
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Lymphoma, Large B-Cell, Diffuse / surgery
  • Male
  • Orchiectomy
  • Testicular Neoplasms / metabolism*
  • Testicular Neoplasms / pathology*
  • Testicular Neoplasms / surgery
  • Testis / pathology
  • Testis / surgery

Substances

  • Biomarkers, Tumor
  • Ki-1 Antigen
  • ACVRL1 protein, human
  • Activin Receptors, Type II