Abstract
Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%+/- 5.9% above those in untreated control cells. Therefore, estradiol may amplify relaxin's actions in the cervix.
MeSH terms
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Cells, Cultured
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Estrogens / pharmacology*
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Female
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Gene Expression Regulation / drug effects*
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Humans
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Polymerase Chain Reaction
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RNA, Messenger / genetics
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Receptors, G-Protein-Coupled / genetics*
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Receptors, Peptide / genetics*
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Uterus / cytology
Substances
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Estrogens
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RNA, Messenger
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RXFP1 protein, human
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Receptors, G-Protein-Coupled
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Receptors, Peptide