Effects of ether vs. ester linkage on lipid bilayer structure and water permeability

Chem Phys Lipids. 2009 Jul;160(1):33-44. doi: 10.1016/j.chemphyslip.2009.04.003. Epub 2009 May 3.

Abstract

The structure and water permeability of bilayers composed of the ether-linked lipid, dihexadecylphosphatidylcholine (DHPC), were studied and compared with the ester-linked lipid, dipalmitoylphosphaditdylcholine (DPPC). Wide angle X-ray scattering on oriented bilayers in the fluid phase indicate that the area per lipid A is slightly larger for DHPC than for DPPC. Low angle X-ray scattering yields A=65.1A(2) for DHPC at 48 degrees C. LAXS data provide the bending modulus, K(C)=4.2x10(-13)erg, and the Hamaker parameter H=7.2x10(-14)erg for the van der Waals attractive interaction between neighboring bilayers. For the low temperature phases with ordered hydrocarbon chains, we confirm the transition from a tilted L(beta') gel phase to an untilted, interdigitated L(beta)I phase as the sample hydrates at 20 degrees C. Our measurement of water permeability, P(f)=0.022cm/s at 48 degrees C for fluid phase DHPC is slightly smaller than that of DPPC (P(f)=0.027cm/s) at 50 degrees C, consistent with our triple slab theory of permeability.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 1,2-Dipalmitoylphosphatidylcholine / chemistry
  • Algorithms
  • Esters / chemistry
  • Ethers / chemistry*
  • Lipid Bilayers / chemistry*
  • Permeability
  • Scattering, Radiation
  • Water / chemistry*

Substances

  • Esters
  • Ethers
  • Lipid Bilayers
  • Water
  • 1,2-Dipalmitoylphosphatidylcholine