Abstract
The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC(50) 0.01 microM). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 microM) than other alkaloids tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Aporphines / isolation & purification
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Aporphines / pharmacology
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Cell Line, Tumor
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Humans
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Leishmania braziliensis / drug effects*
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Molecular Structure
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Plant Extracts / pharmacology
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Trypanocidal Agents / isolation & purification*
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Trypanosoma cruzi / drug effects
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Aporphines
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Plant Extracts
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Trypanocidal Agents
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duguetine
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duguetine beta-N-oxide
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dicentrinone