Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3783-6. doi: 10.1016/j.bmcl.2009.04.071. Epub 2009 Apr 22.

Abstract

We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Furans / chemistry*
  • Hypoxia-Inducible Factor 1 / antagonists & inhibitors*
  • Hypoxia-Inducible Factor 1 / metabolism
  • Lignans / chemical synthesis
  • Lignans / chemistry*
  • Lignans / pharmacology
  • Mice
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Furans
  • Hypoxia-Inducible Factor 1
  • Lignans
  • Vascular Endothelial Growth Factor A
  • tetrahydrofuran
  • manassantin A