Abstract
In this study efficacy of antineoplastic action of gadolinium NCT and boron NCT in cases of canine melanoma and osteosarcoma was compared. Canine spontaneous tumors, such as melanoma and osteosarcoma, have clinical common features with human malignancies, so these tumors in dogs can be considered as clinical model of human melanoma and osteosarcoma. The study has been carried out on 33 dogs with oral cavity melanoma and 9 dogs with osteosarcoma. Dogs with spontaneous melanoma of oral cavity and osteosarcoma of extremities were selected by the results of clinical examination. Irradiation was carried out at the NCT facility of the IRT MEPhI reactor. Neutron irradiation without boron or gadolinium was chosen as a control method to evaluate the efficacy of NCT.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Neoplasms / radiotherapy
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Bone Neoplasms / veterinary
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Boron Compounds / therapeutic use
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Boron Neutron Capture Therapy / veterinary*
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Combined Modality Therapy
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Dog Diseases / radiotherapy*
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Dog Diseases / therapy
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Dogs
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Gadolinium / therapeutic use
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Humans
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Melanoma / radiotherapy
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Melanoma / veterinary
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Mouth Neoplasms / radiotherapy
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Mouth Neoplasms / veterinary
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Neoplasms / radiotherapy
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Neoplasms / therapy
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Neoplasms / veterinary*
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Neutron Capture Therapy / veterinary*
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Osteosarcoma / radiotherapy
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Osteosarcoma / veterinary
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Phenylalanine / analogs & derivatives
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Phenylalanine / therapeutic use
Substances
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Boron Compounds
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Phenylalanine
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Gadolinium
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4-boronophenylalanine