Abstract
The possible interference of tamoxifen with anti-tumor vaccines was studied in a translational view of combined preventive approaches. Tamoxifen treatment of HER-2/neu transgenic mice combined to anti-HER-2/neu cell vaccine did not hamper the efficacy of cancer immunoprevention, and caused a significantly increased production of interferon-gamma. These data suggest that tamoxifen could even have a positive impact on the efficacy of cancer immunoprevention.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents, Hormonal / therapeutic use*
-
Cancer Vaccines / immunology
-
Cancer Vaccines / therapeutic use*
-
Carcinoma / immunology
-
Carcinoma / prevention & control*
-
Cells, Cultured
-
Combined Modality Therapy
-
Female
-
Genes, erbB-2 / genetics
-
Genes, erbB-2 / immunology*
-
Interferon-gamma / biosynthesis
-
Mammary Neoplasms, Experimental / immunology
-
Mammary Neoplasms, Experimental / prevention & control*
-
Mice
-
Mice, Transgenic
-
Spleen / immunology
-
Spleen / metabolism
-
Tamoxifen / therapeutic use*
-
Vaccination
Substances
-
Antineoplastic Agents, Hormonal
-
Cancer Vaccines
-
Tamoxifen
-
Interferon-gamma