XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer

Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):429-35. doi: 10.1093/abbs/gmp027.

Abstract

DNA repair capacity (DRC) is correlated with sensitivity of cancer cells toward platinum-based chemotherapy. We hypothesize that genetic polymorphisms in DNA repair gene XPA (xeroderma pigmentosum group A) and XPG (xeroderma pigmentosum group G) (ERCC5, excision repair cross-complementation group 5), which result in inter-individual differences in DNA repair efficiency, may predict clinical response to platinum agents in advanced non-small cell lung cancer (NSCLC) patients. In this study, we find that the Aright curved arrow G change of XPA A23G polymorphism significantly increased response to platinum-based chemotherapy. Polymorphism in XPG His46His was associated with a decreased treatment response, but was not statistically significant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carboplatin / administration & dosage
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Cisplatin / administration & dosage
  • DNA-Binding Proteins / genetics
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives
  • Docetaxel
  • Endonucleases / genetics
  • Female
  • Gemcitabine
  • Gene Frequency
  • Genotype
  • Humans
  • Logistic Models
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Nuclear Proteins / genetics
  • Paclitaxel / administration & dosage
  • Polymorphism, Single Nucleotide*
  • Taxoids / administration & dosage
  • Transcription Factors / genetics
  • Treatment Outcome
  • Vinblastine / administration & dosage
  • Vinblastine / analogs & derivatives
  • Vinorelbine
  • Xeroderma Pigmentosum Group A Protein / genetics*

Substances

  • DNA excision repair protein ERCC-5
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Taxoids
  • Transcription Factors
  • XPA protein, human
  • Xeroderma Pigmentosum Group A Protein
  • Deoxycytidine
  • Docetaxel
  • Vinblastine
  • Carboplatin
  • Endonucleases
  • Paclitaxel
  • Cisplatin
  • Vinorelbine
  • Gemcitabine