Absence of acetohydroxy acid synthase III in Salmonella typhimurium is due to early termination of translation within the ilvl gene

Mol Microbiol. 1991 Jul;5(7):1741-3. doi: 10.1111/j.1365-2958.1991.tb01923.x.

Abstract

The cryptic ilvlH locus of Salmonella typhimurium has genetic information for two distinct subunits of acetohydroxy acid synthase III. We show that the ilvH-encoded subunit is normally translated and the lack of activity is due to early termination of translation within the promoter-proximal ilvl gene. Analysis of the 5' region of the operon led to identification of the promoter and the amino-terminal part of ilvl. Expression of this gene in a mutant producing acetohydroxy acid synthase is due to a transversion which creates a UUA (leucine) codon in the place of a UGA (stop) codon present in position 12 of the wild-type coding region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetolactate Synthase / biosynthesis
  • Acetolactate Synthase / chemistry
  • Acetolactate Synthase / genetics*
  • Base Sequence
  • Genes, Bacterial
  • Isoenzymes / genetics
  • Molecular Sequence Data
  • Peptide Chain Termination, Translational*
  • Regulatory Sequences, Nucleic Acid
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / growth & development

Substances

  • Isoenzymes
  • Acetolactate Synthase