Unknown ankylosing spondylitis with only cardiac involvement in patient with surgical indication: Call for patient and family members immunological screening

Int J Cardiol. 2009 Nov 12;137(3):e61-2. doi: 10.1016/j.ijcard.2009.04.022. Epub 2009 May 12.

Abstract

Aortic regurgitation (AR) and first-degree atrioventricular heart block (FDAVB) are encountered in ankylosing spondylitis (AS). This rheumatological disease also presents in 90% of the cases an immunogenetic marker that is Human Leucocyte Antigen-B27 (HLA-B27). In this report we describe a case of a patient presenting with AR, FDAVB, aneurysm and thinning of the ascending aortic wall, aneurysm of the sinuses of Valsalva and inferior myocardial infarction-like electrocardiographic pattern with unknown cardiac AS and absence of other AS-related systemic manifestations.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aortic Valve Insufficiency / diagnosis
  • Aortic Valve Insufficiency / genetics
  • Aortic Valve Insufficiency / immunology*
  • Aortic Valve Insufficiency / physiopathology
  • Coronary Angiography
  • Echocardiography, Transesophageal
  • Electrocardiography
  • HLA-B27 Antigen / immunology*
  • Heart Aneurysm / diagnosis
  • Heart Aneurysm / genetics
  • Heart Aneurysm / immunology*
  • Heart Aneurysm / physiopathology
  • Heart Block / diagnosis
  • Heart Block / genetics
  • Heart Block / immunology*
  • Heart Block / physiopathology
  • Humans
  • Inferior Wall Myocardial Infarction / diagnosis
  • Inferior Wall Myocardial Infarction / genetics
  • Inferior Wall Myocardial Infarction / immunology*
  • Inferior Wall Myocardial Infarction / physiopathology
  • Male
  • Middle Aged
  • Spondylitis, Ankylosing / diagnosis
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / immunology*
  • Spondylitis, Ankylosing / physiopathology

Substances

  • HLA-B27 Antigen