Abstract
We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms
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Genotype
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HIV Envelope Protein gp120 / genetics*
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HIV-1 / genetics*
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HIV-1 / physiology
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Humans
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Molecular Sequence Data
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Receptors, Virus*
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Sensitivity and Specificity
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Sequence Analysis, DNA
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Virus Attachment*
Substances
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HIV Envelope Protein gp120
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Receptors, Virus
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gp120 protein, Human immunodeficiency virus 1
Associated data
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GENBANK/FJ652327
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GENBANK/FJ652328
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