Abstract
ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of life. Tumor therapy requires information about molecular alterations, thus we studied expression of ErbB receptor and ligand genes by real-time RT-PCR in different meningioma grades. Receptors were overexpressed (ErbB1, ErbB2) or underexpressed (ErbB3, ErbB4). Ligands EGF, TGFA, AREG, DTR, BTD were underexpressed and the neuregulins were overexpressed or underexpressed. A strong ErbB1-ErbB2 correlation was found. These data might be useful for gene therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Amphiregulin
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Betacellulin
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EGF Family of Proteins
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Epidermal Growth Factor / genetics
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Epigen
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ErbB Receptors / genetics
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Female
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Gene Expression Profiling* / methods
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Gene Expression Regulation, Neoplastic*
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Genes, erbB*
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Glycoproteins / genetics
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Heparin-binding EGF-like Growth Factor
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Humans
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Intercellular Signaling Peptides and Proteins / genetics*
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Ligands
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Male
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Meningeal Neoplasms / genetics*
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Meningeal Neoplasms / pathology
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Meningioma / genetics*
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Meningioma / pathology
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Middle Aged
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Neoplasm Staging
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Neuregulins / genetics
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Polymerase Chain Reaction
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RNA, Messenger / metabolism
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Receptor, ErbB-2 / genetics
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Receptor, ErbB-4
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Transforming Growth Factor alpha / genetics
Substances
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AREG protein, human
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Amphiregulin
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BTC protein, human
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Betacellulin
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EGF Family of Proteins
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EPGN protein, human
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Epigen
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Glycoproteins
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HBEGF protein, human
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Heparin-binding EGF-like Growth Factor
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Intercellular Signaling Peptides and Proteins
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Ligands
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Neuregulins
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RNA, Messenger
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Transforming Growth Factor alpha
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Epidermal Growth Factor
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EGFR protein, human
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ERBB2 protein, human
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ERBB4 protein, human
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ErbB Receptors
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Receptor, ErbB-2
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Receptor, ErbB-4