Abstract
Antiviral efficacy of Ingavirin was studied on albino mice infected intranasally by the grippe A virus (H3N2) vs. Tamiflu, Remantadin and Arbidol. Ingavirin used prophylactically in doses of 5 to 10 mg/kg was shown to be effective in protecting the animals from death and inhibiting the specific hemagglutinin formation and the virus reproduction in the lungs (by the accumulation).
MeSH terms
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Amides
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Animals
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Antiviral Agents / pharmacology*
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Caproates
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Dicarboxylic Acids
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Dose-Response Relationship, Drug
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Hemagglutinins, Viral / blood
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Humans
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Imidazoles
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Influenza A Virus, H3N2 Subtype*
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Influenza, Human / blood
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Influenza, Human / prevention & control*
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Lung / virology
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Mice
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Russia
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Virus Replication / drug effects
Substances
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Amides
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Antiviral Agents
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Caproates
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Dicarboxylic Acids
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Hemagglutinins, Viral
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Imidazoles
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pentanedioic acid imidazolyl ethanamide