Abstract
Cytoadherence to CD36 and ICAM-1 and var gene expression of P. falciparum parasites from a splenectomized patient were studied. These parasites lacked cytoadherence and showed expression of a non-coding cDNA sequence. Hence the spleen's modulation of parasite cytoadherence by mechanisms that affect the parasite's surface antigen expression is suggested.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
CD36 Antigens / metabolism
-
CHO Cells
-
Cell Adhesion / physiology*
-
Cricetinae
-
Cricetulus
-
Female
-
Humans
-
Intercellular Adhesion Molecule-1 / metabolism
-
Male
-
Middle Aged
-
Plasmodium falciparum / genetics
-
Plasmodium falciparum / metabolism
-
Plasmodium falciparum / pathogenicity
-
Plasmodium falciparum / physiology*
-
Protozoan Proteins / genetics
-
Protozoan Proteins / metabolism
-
Spleen / metabolism
-
Spleen / parasitology*
Substances
-
CD36 Antigens
-
Protozoan Proteins
-
erythrocyte membrane protein 1, Plasmodium falciparum
-
Intercellular Adhesion Molecule-1